Difference in Intestinal Flora Among Patients with Esophageal Squamous Cell Carcinoma and Normal Population

Autor: CAO Yanzhen, TUSUNAYI·Wumaier, HU Jiajie, YANG Lili, FANG Xinzhi
Jazyk: čínština
Rok vydání: 2023
Předmět:
Zdroj: Zhongliu Fangzhi Yanjiu, Vol 50, Iss 9, Pp 873-878 (2023)
Druh dokumentu: article
ISSN: 1000-8578
DOI: 10.3971/j.issn.1000-8578.2023.23.0297
Popis: Objective To investigate the difference in intestinal flora among patients with esophageal squamous cell carcinoma and normal population and to provide a basis for the early diagnosis of esophageal squamous cell carcinoma as a marker. Methods DNA was extracted from biopsy tissue samples of 30 patients with esophageal squamous cell carcinoma (observation group) and 25 healthy people (control group) by microbial amplification sequencing. The integrity and quality of DNA were detected. The composition and abundance of intestinal flora in the samples of the two groups were determined. Results A great similarity in beta diversity was found between the two groups, but some differences were also observed. The relative abundance of Proteobacteria and Verrucomicrobia in the observation group was higher than that in the control group (P
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