Study of cell death and stages of leukocytes apoptosis in pulmonary tuberculosis patients with different antimycobacterial treatments
| Autor: | Olga S. SHEVCHENKO, Oksana A. NAKONECHNA, Liliia D. TODORIKO, Olga O. HOVARDOVSKA, Olga O. POHORIELOVA, Sergey B. VOLF, Olena V. PIDVERBETSKA, Iryna Ya. MAKOYDA, Victor I. SLYVKA |
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| Jazyk: | English<br />French |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Archives of the Balkan Medical Union, Vol 54, Iss 4, Pp 692-698 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1584-9244 2558-815X |
| DOI: | 10.31688/ABMU.2019.54.4.11 |
| Popis: | The aim of the study was to evaluate the condition of cytoplasmic membranes of leukocytes and to study their viability, to determine the varieties and stages of cell death of leukocytes in patients with pulmonary tuberculosis treated by different schemes of antimycobacterial treatment. Materials and methods. The study was performed on 30 patients with pulmonary tuberculosis: the 1st group – 12 patients treated by standard regimen with 1st line drugs; the 2nd group treated by individual regimen with 1st and 2nd line drugs. Results. The analysis of cytoplasmic membranes of leukocytes in the blood of patients from the 1st and the 2nd group showed that the proportion of live intact cells was 71.05±3.66%, that is lower by 20.75 % from the results of control group. In the 2nd group, the proportion of alive cells was lower by 12.9% than in the 1st group (р |
| Databáze: | Directory of Open Access Journals |
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