Increased baroreceptor sensitivity in a patient with hereditary spastic paraplegia – type SPG11

Autor: Fischer Gerald, Baumgartner Sigl Sara, Baumgarten Daniel, Fortin Jürgen
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Current Directions in Biomedical Engineering, Vol 4, Iss 1, Pp 497-499 (2018)
Druh dokumentu: article
ISSN: 2364-5504
DOI: 10.1515/cdbme-2018-0119
Popis: An 18 years old male patient was diagnosed with genetically confirmed hereditary spastic paraplegia of type SPG11 - a rare disease of neurodegeneration. During normal clinical routine investigation, he presented with a moderate sinus bradycardia. The function of the cardiovascular system was investigated by recording electrocardiogram, impedance cardiogram and continuous blood pressure non-invasively. Cardiac function appeared normal in all modalities. Baroreflex sensitivity was strongly increased by a factor of 2.8. Results indicate that further to hyperactivity of deep tendon reflexes, also the responsiveness regarding control of heart rhythm by baroreceptors is significantly increased. This finding provides evidence for the impact of a neurological disorder onto the cardiovascular system and its autonomic control.
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