Hydrolysis of Methionine- and Histidine-Containing Peptides Promoted by Dinuclear Platinum(II) Complexes with Benzodiazines as Bridging Ligands: Influence of Ligand Structure on the Catalytic Ability of Platinum(II) Complexes

Autor: Snežana Rajković, Beata Warżajtis, Marija D. Živković, Biljana Đ. Glišić, Urszula Rychlewska, Miloš I. Djuran
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Bioinorganic Chemistry and Applications, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 1565-3633
1687-479X
DOI: 10.1155/2018/3294948
Popis: Dinuclear platinum(II) complexes, [{Pt(en)Cl}2(μ-qx)]Cl2·2H2O (1), [{Pt(en)Cl}2(μ-qz)](ClO4)2 (2), and [{Pt(en)Cl}2(μ-phtz)]Cl2·4H2O (3), were synthesized and characterized by different spectroscopic techniques. The crystal structure of 1 was determined by single-crystal X-ray diffraction analysis, while the DFT M06-2X method was applied in order to optimize the structures of 1–3. The chlorido Pt(II) complexes 1–3 were converted into the corresponding aqua species 1a–3a, and their reactions with an equimolar amount of Ac–L–Met–Gly and Ac–L–His–Gly dipeptides were studied by 1H NMR spectroscopy in the pH range 2.0
Databáze: Directory of Open Access Journals
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