Parcellation-Based Connectivity Model of the Judgement Core

Autor: Jorge Hormovas, Nicholas B. Dadario, Si Jie Tang, Peter Nicholas, Vukshitha Dhanaraj, Isabella Young, Stephane Doyen, Michael E. Sughrue
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Personalized Medicine, Vol 13, Iss 9, p 1384 (2023)
Druh dokumentu: article
ISSN: 2075-4426
DOI: 10.3390/jpm13091384
Popis: Judgement is a higher-order brain function utilized in the evaluation process of problem solving. However, heterogeneity in the task methodology based on the many definitions of judgement and its expansive and nuanced applications have prevented the identification of a unified cortical model at a level of granularity necessary for clinical translation. Forty-six task-based fMRI studies were used to generate activation-likelihood estimations (ALE) across moral, social, risky, and interpersonal judgement paradigms. Cortical parcellations overlapping these ALEs were used to delineate patterns in neurocognitive network engagement for the four judgement tasks. Moral judgement involved the bilateral superior frontal gyri, right temporal gyri, and left parietal lobe. Social judgement demonstrated a left-dominant frontoparietal network with engagement of right-sided temporal limbic regions. Moral and social judgement tasks evoked mutual engagement of the bilateral DMN. Both interpersonal and risk judgement were shown to involve a right-sided frontoparietal network with accompanying engagement of the left insular cortex, converging at the right-sided CEN. Cortical activation in normophysiological judgement function followed two separable patterns involving the large-scale neurocognitive networks. Specifically, the DMN was found to subserve judgement centered around social inferences and moral cognition, while the CEN subserved tasks involving probabilistic reasoning, risk estimation, and strategic contemplation.
Databáze: Directory of Open Access Journals