Early cyclosporin A treatment retards axonal degeneration in an experimental peripheral nerve injection injury model
| Autor: | Ibrahim Erkutlu, Mehmet Alptekin, Sirma Geyik, Abidin Murat Geyik, Inan Gezgin, Abdulvahap Gök |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Alzheimer′s disease
amyloid-β astrocytes Ca 2+ calcilytic calcium-sensing receptor nitromemantine NPS 2143 α7-nicotinic acetylcholine receptor nerve regeneration spinal cord injury surgical decompression tumor necrosis factor α cell apoptosis neurological function neural regeneration contusion Nogo-A axon growth immunohistochemistry fluorescent quantitative PCR Schwann cells cell transplantation edaravone motor function electrophysiological function electroacupuncture intervertebral disc blood circulation inflammation neuroprotection neurons NSFC grants astrocytoma mice immunodeficiency (BALB/c) mice Notch nestin glial fibrillary acidic protein CD133 spinal cord brain MRI earthquake peripheral nerve injury LSUHSC score compartment syndrome surgery therapy physiotherapy nerve decompression brachial plexus injury human amniotic epithelial cells forepaw function stress relaxation creep viscoelasticity injection injury cyclosporine A penicillin G potassium Wallerian degeneration neuroelectrophysiology Neurology. Diseases of the nervous system RC346-429 |
| Zdroj: | Neural Regeneration Research, Vol 10, Iss 2, Pp 266-270 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1673-5374 |
| DOI: | 10.4103/1673-5374.152381 |
| Popis: | Injury to peripheral nerves during injections of therapeutic agents such as penicillin G potassium is common in developing countries. It has been shown that cyclosporin A, a powerful immunosuppressive agent, can retard Wallerian degeneration after peripheral nerve crush injury. However, few studies are reported on the effects of cyclosporin A on peripheral nerve drug injection injury. This study aimed to assess the time-dependent efficacy of cyclosporine-A as an immunosuppressant therapy in an experimental rat nerve injection injury model established by penicillin G potassium injection. The rats were randomly divided into three groups based on the length of time after nerve injury induced by penicillin G potassium administration (30 minutes, 8 or 24 hours). The compound muscle action potentials were recorded pre-injury, early post-injury (within 1 hour) and 4 weeks after injury and compared statistically. Tissue samples were taken from each animal for histological analysis. Compared to the control group, a significant improvement of the compound muscle action potential amplitude value was observed only when cyclosporine-A was administered within 30 minutes of the injection injury (P < 0.05); at 8 or 24 hours after cyclosporine-A administration, compound muscle action potential amplitude was not changed compared with the control group. Thus, early immunosuppressant drug therapy may be a good alternative neuroprotective therapy option in experimental nerve injection injury induced by penicillin G potassium injection. |
| Databáze: | Directory of Open Access Journals |
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