GDF9 and BMP15 Expressions and Fine Structure Changes During Folliculogenesis in Polycystic Ovary Syndrome

Autor: Meryem İlkay Karagül, Savaş Aktaş, Banu Coşkun Yılmaz, Mustafa Yılmaz, Gülhan Örekiçi Temel
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Balkan Medical Journal, Vol 35, Iss 1, Pp 43-54 (2018)
Druh dokumentu: article
ISSN: 2146-3123
2146-3131
DOI: 10.4274/balkanmedj.2016.1110
Popis: Background: Polycystic ovary syndrome is the most frequently seen endocrine disorder in women of reproductive age with a prevalence of about 10%. Aims: To investigate the efficiency of growth differentiation factor 9 and bone morphogenetic protein 15 during folliculogenesis in a dehydroepiandrosterone-induced mouse Polycystic ovary syndrome model. Study Design: Animal experimentation. Methods: Mice were divided into 3 groups: control, vehicle and Polycystic ovary syndrome. Polycystic ovary syndrome model mice were developed by the injection of dehydroepiandrosterone dissolved in 0.1 mL of sesame oil. Ovarian tissues were examined for growth differentiation factor 9 and bone morphogenetic protein 15 using immunofluorescent labelling and electron microscopic examinations. Results: The immunoreactivity of growth differentiation factor 9 and bone morphogenetic protein 15 proteins decreased (p
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