Ureteral metastasis of small cell lung cancer transformed from lung adenocarcinoma: A case report

Autor: Yi Wang, Ji Li, Lei Luo, Xiaoliang Li, Qingsong Liu, Yan Wang, Guowei Che, Xiaoyang Xie
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Thoracic Cancer, Vol 13, Iss 11, Pp 1731-1734 (2022)
Druh dokumentu: article
ISSN: 1759-7714
1759-7706
DOI: 10.1111/1759-7714.14435
Popis: Abstract Targeted therapy offers a new option for patients with advanced lung adenocarcinoma patients. However, long‐term targeted therapy may transform lung adenocarcinoma into small cell lung cancer (SCLC). Herein, we report a 48‐year‐old female patient with pulmonary adenocarcinoma and ureteral metastasis which transformed from adenocarcinoma to SCLC after surgical and targeted therapies. She was diagnosed with invasive adenocarcinoma undergoing the surgery. Two years later recurrence and metastasis occurred and she was given targeted therapy with gefitinib and osimertinib. Two years after targeted therapy, a right ureteral mass (4.9 × 3.7 × 3.8 cm) pathologically diagnosed with SCLC was found, which indicated that the pathological subtype has changed from adenocarcinoma to SCLC. Ultimately, multiple metastases occurred after two cycles of chemotherapy consisting of cis‐platinum plus etoposide.
Databáze: Directory of Open Access Journals
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