Exploring the interaction mechanisms between cervical carcinoma in situ and antibody-mediated immune responses through Mendelian randomization analysis

Autor: Junfei Li, Lihuang He, Qun He, Kaihong Xie, Hui Xie
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Discover Oncology, Vol 15, Iss 1, Pp 1-11 (2024)
Druh dokumentu: article
ISSN: 2730-6011
DOI: 10.1007/s12672-024-01456-5
Popis: Abstract Objective This study aims to investigate the causal relationship between cervical carcinoma in situ and antibody-mediated immune responses, providing a scientific basis for the prevention and treatment of cervical carcinoma in situ. Methods A bidirectional Mendelian Randomization (MR) approach was utilized, leveraging two Genome-Wide Association Studies (GWAS) related to cervical carcinoma in situ and antibody-mediated immune responses to collect Single Nucleotide Polymorphism (SNP) data. Multiple statistical methods, including the inverse-variance weighted (IVW) method, MR-Egger regression, weighted median, and weighted mode, were utilized. Antibody-mediated immune response-related SNPs were used as instrumental variables (IVs) for a forward MR analysis of cervical carcinoma in situ, while cervical carcinoma in situ-related SNPs served as IVs for a reverse MR analysis of antibody-mediated immune responses. Results The forward MR analysis revealed significant causal associations between two SNPs, GCST90006901 (P = 0.012, OR (95%CI) = 1.167(1.034–1.317)) and GCST90006909 (P
Databáze: Directory of Open Access Journals
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