Impact of subthreshold depression on health-related quality of life in patients with Parkinson’s disease based on cognitive status

Autor:	Aline Schönenberg, Hannah M. Zipprich, Ulrike Teschner, Julian Grosskreutz, Otto W. Witte, Tino Prell
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Subthreshold depression Dementia Quality of life Parkinson’s disease Cognitive impairment Non-motor symptoms Computer applications to medicine. Medical informatics R858-859.7
Zdroj:	Health and Quality of Life Outcomes, Vol 19, Iss 1, Pp 1-8 (2021)
Druh dokumentu:	article
ISSN:	1477-7525
DOI:	10.1186/s12955-021-01753-5
Popis:	Abstract Background In patients with Parkinson’s disease (PD), depression has a strong impact on quality of life (QoL). However, little is known about the influence of subthreshold depression (STD) on QoL in PD patients. Methods A total of 230 hospitalized PD patients with normal and impaired cognitive status were included in this observational study. We collected the following data for analysis: Beck Depression Inventory level, Montreal Cognitive Assessment (MOCA) score, non-motor symptoms questionnaire score, PD questionnaire-39 (PDQ-39) score, Hoehn–Yahr stage, and Movement Disorder Society-sponsored revision of the unified PD rating scale III (MDS-UPDRS III) score. To study the impact of STD on the PDQ-39 summary index (SI) and its domains, we used multivariate analysis of variance and multivariate analysis of covariance. Results In this cohort, 80 (34.8%) patients had STD [44 (32.3%) with high MOCA score (> 21) and 36 (38.3%) with low MOCA score (
Databáze:	Directory of Open Access Journals
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