Targeting ATR/CHK1 pathway in acute myeloid leukemia to overcome chemoresistance

Autor:	Laure David, Stéphane Manenti, Christian Récher, Jean-Sébastien Hoffmann, Christine Didier
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	acute myeloid leukemia atr and chk1 kinases chemoresistance dna replicative stress Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Molecular & Cellular Oncology, Vol 4, Iss 5 (2017)
Druh dokumentu:	article
ISSN:	2372-3556 23723556
DOI:	10.1080/23723556.2017.1289293
Popis:	Resistance of acute myeloid leukemia to current therapies leads to frequent relapses. Identification of molecular mechanisms involved in chemoresistance constitutes a key challenge to define new therapeutic concepts. Here, we show that the ATR/CHK1 pathway, essential in maintaining genomic stability, is involved in resistance and proliferation characteristics of leukemic cells.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c39976d70e79476c93587d98544c7e03 Zobrazit plný text záznamu View record in DOAJ