| Autor: |
Tvrdík Tomáš, Melicherčík Ľubomír, Šebeková Katarína, Szabó Jakub, Maková Marianna, Gogola Daniel, Kašparová Svatava |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Measurement Science Review, Vol 23, Iss 5, Pp 237-247 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1335-8871 |
| DOI: |
10.2478/msr-2023-0030 |
| Popis: |
The aim of our study was to develop a multimodal experimental protocol for in vivo imaging and metabolic parameters (MRI, DTI and 1H MRS) in an animal model of neurodegeneration. We have successfully developed the protocol for simultaneous DTI/MRI/1H MRS measurement to ensure unaltered conditions for repeatable non-invasive experiments. In this experiment, diffusion tensor imaging, spectroscopic and volumetric “bio-markers” were generated in the brain for the D-galactose model of “age-related dementia”. The hippocampal relative volume, taurine and myo-inositol relative concentrations were found to be significant predictors contributing to the differences between the groups of rats treated with D-galactose in simulated “neurodegeneration”, even in response to the applied Huperzine A therapy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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