Central obesity and elevated blood pressure in middle life are associated with physical and cognitive impairment in later life: A retrospective design with repeated measures

Autor: Shao-Yuan Chuang, Wen-Ling Liu, Hsing-Yi Chang, Chih-Cheng Hsu, Wen-Harn Pan
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Experimental Gerontology, Vol 173, Iss , Pp 112093- (2023)
Druh dokumentu: article
ISSN: 1873-6815
DOI: 10.1016/j.exger.2023.112093
Popis: Background and aims: Physical and cognitive function decline indicates the prestage of disability and is associated with mortality among older adults. We investigated the association of metabolic disorders in midlife with physical and cognitive function decline in later life in a retrospective cohort. Material and methods: A total of 618 older adults aged ≥60 years in wave-6 (2014–2017) were enrolled in the Cardiovascular Disease Risk Factor Two-Township Study to evaluate physical (hand grip strength and 4-m walking speed) and cognitive function (Mine–Mental State Examination [MMSE] score). Repeated metabolic disorder measures in wave-2, wave-3, and wave-5 were obtained to identify three trajectory pattern groups according to each metabolic disorder through group-based trajectory modeling. Linear and logistic regressions were conducted to investigate the association of metabolic disorders in middle life with physical and cognitive function decline in later life. Results: The prevalence rates of a weak hand grip (
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