| Autor: |
Abdulraheem Y. Majeed, Nor Effa S. Zulkafli, Ali H. Ad’hiah |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Beni-Suef University Journal of Basic and Applied Sciences, Vol 12, Iss 1, Pp 1-9 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2314-8543 |
| DOI: |
10.1186/s43088-023-00367-8 |
| Popis: |
Abstract Background This study analyzed serum concentrations of interleukin (IL)-22 and IL-33 (pro-inflammatory and anti-inflammatory cytokines) in 90 patients with mild/moderate coronavirus disease 2019 (COVID-19) and 90 healthy controls. Enzyme-linked immunosorbent assay kits were used to measure IL-22 and IL-33 concentrations. Results Median (interquartile range) concentrations of IL-22 and IL-33 were significantly higher in patients than in controls (IL-22: 18.6 [18.0–19.3] vs. 13.9 [12.1–14.9] pg/mL, probability [p] control median) of IL-22 (odds ratio = 17.80 [95% CI: 6.48–48.90]; p = 0.001) and IL-33 (odds ratio = 19.0 [95% CI: 7.4–48.6]; p = 0.001) were more likely to develop COVID-19. A positive correlation was found between IL-22 and IL-33 and both cytokines also showed positive correlations with granulocyte-to-lymphocyte ratio and erythrocyte sedimentation rate in all participants. Conclusions IL-22 and IL-33 showed up-regulated concentrations in the serum of patients with mild/moderate COVID-19. Both cytokines may have prognostic value for COVID-19 along with their association with disease risk. |
| Databáze: |
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| Externí odkaz: |
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