Acute Stent Thrombosis Associated with Eptifibatide-Induced Profound Thrombocytopenia

Autor: Amer Aljundi, Alaa Rahhal, Wafer Dabdoob
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Case Reports in Cardiology, Vol 2020 (2020)
Druh dokumentu: article
ISSN: 2090-6404
2090-6412
DOI: 10.1155/2020/8386709
Popis: Background. Eptifibatide is an inhibitor of the platelet glycoprotein (GP) IIb/IIIa receptor that is commonly used in patients undergoing percutaneous coronary intervention (PCI). Case. We describe a case of a 62-year-old female patient admitted with acute ST-elevation myocardial infarction (STEMI) treated by primary coronary intervention (primary PCI) with a drug-eluting stent placement. She developed profound thrombocytopenia within 8 hours of first administration of eptifibatide and subsequent acute stent thrombosis next day. Other causes of thrombocytopenia were excluded and intravascular ultrasound (IVUS) showed good stent expansion and opposition to the coronary wall. Platelet count gradually returned to normal after discontinuation of eptifibatide. Conclusion. Although Eptifibatide has been associated with the development of thrombocytopenia, to the best of our knowledge, this is the first case report in the medical literature that associates acute stent thrombosis and eptifibatide-induced thrombocytopenia.
Databáze: Directory of Open Access Journals
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