CD28-CD57+ T cells from head and neck cancer patients produce high levels of cytotoxic granules and type II interferon but are not senescent
| Autor: | Brendan L.C. Kinney, Brianna Brammer, Vikash Kansal, Connor J. Parrish, Haydn T. Kissick, Yuan Liu, Nabil F. Saba, Zachary S. Buchwald, Mark W. El-Deiry, Mihir R. Patel, Brian J. Boyce, Azeem S. Kaka, Jennifer H. Gross, H. Michael Baddour, Amy Y. Chen, Nicole C. Schmitt |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | OncoImmunology, Vol 13, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2162402X 2162-402X |
| DOI: | 10.1080/2162402X.2024.2367777 |
| Popis: | T lymphocytes expressing CD57 and lacking costimulatory receptors CD27/CD28 have been reported to accumulate with aging, chronic infection, and cancer. These cells are described as senescent, with inability to proliferate but enhanced cytolytic and cytokine-producing capacity. However, robust functional studies on these cells taken directly from cancer patients are lacking. We isolated these T cells and their CD27/28+ counterparts from blood and tumor samples of 50 patients with previously untreated head and neck cancer. Functional studies confirmed that these cells have enhanced ability to degranulate and produce IFN-γ. They also retain the ability to proliferate, thus are not senescent. These data suggest that CD27/28-CD57+ CD8+ T cells are a subset of highly differentiated, CD45RA+ effector memory (TEMRA) cells with retained proliferative capacity. Patients with > 34% of these cells among CD8+ T cells in the blood had a higher rate of locoregional disease relapse, suggesting these cells may have prognostic significance. |
| Databáze: | Directory of Open Access Journals |
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