| Autor: |
Jing Li, Xiaoling Lyu, Pan Wang, Bao Ting Zhu |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 110, Iss , Pp 105827- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2023.105827 |
| Popis: |
Alzheimer’s disease (AD) is a common form of neurodegeneration. In this study, we investigated the modulating effect of bilberry anthocyanins (BAs) on AD-like pathology in the APP/PSEN1 transgenic mouse and then explored the underlying mechanisms using the HT22 cells. We found that BAs significantly reduced the amyloid plaque load and the levels of β-amyloid 1–42 (Aβ42) in the brain and serum of APP/PSEN1 mice. Furthermore, BAs improved mitochondrial morphology and reduced brain NO and ROS levels in the APP/PSEN1 mice. Additional experiments using immortalized HT22 cells showed that BAs protected against Aβ42-induced cytotoxicity by reducing ROS levels and restoring mitochondrial homeostasis, and these effects were partly mediated by upregulation of the mitochondrial homeostasis-related protein Mfn2 via promoting the interaction between β-catenin and TCF7 in nuclear. Together, the results show that BAs have a protective effect against the development of AD, partly through restoration of mitochondrial homeostasis in a β-catenin/TCF-dependent manner. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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