| Autor: |
Yvonne L. Dorland, Tsveta S. Malinova, Anne-Marieke D. van Stalborch, Adam G. Grieve, Daphne van Geemen, Nicolette S. Jansen, Bart-Jan de Kreuk, Kalim Nawaz, Jeroen Kole, Dirk Geerts, René J. P. Musters, Johan de Rooij, Peter L. Hordijk, Stephan Huveneers |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/ncomms12210 |
| Popis: |
Cell-cell adhesion of endothelial tissue, mediated by the adhesion molecule VE-cadherin, is tightly regulated. Here the authors show that the F-BAR domain protein pacsin2 is recruited to the trailing end of mechanically unbalanced Focal Adherens Junctions, where it inhibits internalization of VE-cadherin and protects cell-cell adhesion. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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