Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression

Autor:	Ruifang Sun, Yang Yang, Weidong Lü, Yanqi Yang, Yulong Li, Zhigang Liu, Dongmei Diao, Yang Wang, Su’e Chang, Mengnan Lu, Qiuyu Jiang, Bingling Dai, Xiaobin Ma, Chang’an Zhao, Moqi Lü, Juan Zhang, Caixia Ding, Na Li, Jian Zhang, Zhengtao Xiao, Dangxia Zhou, Chen Huang
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Single cell Colon adenoma Colon cancer Cancer development Biotechnology TP248.13-248.65 Biology (General) QH301-705.5 Biochemistry QD415-436
Zdroj:	Cell & Bioscience, Vol 13, Iss 1, Pp 1-15 (2023)
Druh dokumentu:	article
ISSN:	2045-3701
DOI:	10.1186/s13578-023-01002-w
Popis:	Highlights We performed single-cell transcriptome sequencing in one case carrying adenoma and carcinoma, and explored process of colon cancer progression. Results suggest the presence of dominant clones of same cells including C2 goblet cell, epithelial cell subtype 1 (Epi1), enterocyte cell subset 0 (Entero0), and Entero5 in colon carcinoma We discovered new colon cancer related genes including AC007952.4, NEK8, CHRM3, ANO7, B3GNT6, NEURL1, ODC1 and KCNMA1. The function of TBC1D4, LTB, C2CD4A, AND GBP4/5 in T cells needs to be clarified.
Databáze:	Directory of Open Access Journals
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