| Autor: |
Anand K. Agrahari, Sunil Kumar, Anindra Sharma, Vinod K. Tiwari |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of Chemistry, Vol 2021 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2090-9071 |
| DOI: |
10.1155/2021/4209514 |
| Popis: |
High-sugar-tethered glycodendrimers are a remarkable tool in glycobiology for the investigation of carbohydrate-protein interaction using its multivalency property. An enthralling double-stage convergent synthetic approach was selected to build a novel class of chlorine-containing glucose-coated dendrimers using an efficient click catalyst ‘dinuclear copper(I) thiodiacetate complex.’ In this context, cyclen core was developed through a divergent approach, while the glucodendron was developed via a convergent approach independently. Both azide-alkyne partners were coupled through a modular copper azide-alkyne cycloaddition (CuAAC) strategy to afford a high yield of the desired 36-glucose-coated glycodendrimer. The synthesized glycodendrimer has been elucidated by NMR, gel permeation chromatography (GPC), and IR spectral analysis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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