| Autor: |
Arata Ishii, Shokichi Tsukamoto, Tatsuzo Mishina, Shintaro Izumi, Yurie Nagai, Miki Yamazaki, Yutaro Hino, Kensuke Kayamori, Nagisa Oshima-Hasegawa, Tomoya Muto, Shio Mitsukawa, Yusuke Takeda, Naoya Mimura, Chikako Ohwada, Chiaki Nakaseko, Jun-ichiro Ikeda, Emiko Sakaida |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Leukemia Research Reports, Vol 16, Iss , Pp 100278- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2213-0489 |
| DOI: |
10.1016/j.lrr.2021.100278 |
| Popis: |
A 45-year-old woman was diagnosed with myelodysplastic syndrome (MDS) with trisomy 8 and Behçet-like disease (BLD) with multiple colorectal ulcers. Nonspecific inflammatory cells were infiltrated in the intestinal mucosa, whereas fluorescence in situ hybridization (FISH) analysis revealed only sporadic trisomy 8-positive cells. She presented massive lower gastrointestinal bleeding early after bone marrow transplantation but achieved long-term remission of both MDS and BLD. This is the first report of massive gastrointestinal bleeding after transplantation for MDS with BLD. Based on FISH analysis, dysregulation of systemic inflammation may be involved in BLD rather than direct invasion by trisomy 8-positive MDS clones. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
