3L, Three-Lactobacilli on Recovering of Microbiome and Immune-Damage by Cyclophosphamide Chemotherapy—A Pilot Experiment in Rats

Autor:	Shousong Yue, Zhenzhong Zhang, Fei Bian, Yan Zhang, Gao Chen, Youfeng Zhu, Jun Li, Jean-François Picimbon
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Illumina MiSeq sequencing gut microflora Lactobacillus immunostimulant adjuvant anticancer bioproduct Microbiology QR1-502
Zdroj:	Microbiology Research, Vol 14, Iss 3, Pp 831-869 (2023)
Druh dokumentu:	article
ISSN:	2036-7481
DOI:	10.3390/microbiolres14030059
Popis:	We deal with various strains of Lactobacillus that can maintain the intestinal microbiome of rats treated with cyclophosphamide, an anticancer agent (chemotherapy). We use MiSeq and various types of statistical tests to prove that cyclophosphamide in rats alters the intestinal microbiome, favoring the growth of various fungi that are extremely harmful to intestinal metabolism. On the contrary, when Lactobacillus 3L is administered together with cyclophosphamide, we prove that the microbiome is preserved by having a much better intestinal metabolism.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/3938159d18c641ab97abf3b1d429f2de Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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