Prevalence of anti-nuclear autoantibodies in subjects exposed to natural asbestiform fibers: a cross-sectional study

Autor: Caterina Ledda, Rosario Caltabiano, Carla Loreto, Diana Cinà, Paola Senia, Andrea Musumeci, Vincenzo Ricceri, Cristoforo Pomara, Venerando Rapisarda
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Journal of Immunotoxicology, Vol 15, Iss 1, Pp 24-28 (2018)
Druh dokumentu: article
ISSN: 1547-691X
1547-6901
1547691X
DOI: 10.1080/1547691X.2017.1415398
Popis: Fluoro-edenite (FE) is an asbestiform mineral fiber spotted in the lava rocks excavated from a stone quarry in Biancavilla (Italy). The derived material had been employed locally for building purposes. Previous studies found evidence that exposure to asbestos may induce autoimmunity, with frequency of anti-nuclear autoantibodies (ANA). The aim of this study was to explore the relationship between FE exposure and autoimmune responses in an exposed population. For the study, 60 subjects living in the area of Biancavilla and 60 subjects as control group were randomly invited to participate. A free medical check, including spirometry and a high-resolution computer tomography chest scan, was given to all participants. ANA were determined by indirect immunofluorescence. On medical check, no subject showed any sign and/or symptoms of illness. Prevalence for samples positive to ANA were 70% (n = 42) and 25% (n = 15), respectively, for exposed and non-exposed subjects (p
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