| Autor: |
Alberto Arrigoni, Mattia Previtali, Sara Bosticardo, Giulio Pezzetti, Sofia Poloni, Serena Capelli, Angela Napolitano, Andrea Remuzzi, Rosalia Zangari, Ferdinando Luca Lorini, Maria Sessa, Alessandro Daducci, Anna Caroli, Simonetta Gerevini |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
NeuroImage: Clinical, Vol 43, Iss , Pp 103631- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2213-1582 |
| DOI: |
10.1016/j.nicl.2024.103631 |
| Popis: |
Introduction: The COVID-19 pandemic has affected millions worldwide, causing mortality and multi-organ morbidity. Neurological complications have been recognized. This study aimed to assess brain structural, microstructural, and connectivity alterations in patients with COVID-19-related olfactory or cognitive impairment using post-acute (time from onset: 264[208–313] days) multi-directional diffusion-weighted MRI (DW-MRI). Methods: The study included 16 COVID-19 patients with cognitive impairment (COVID-CM), 35 COVID-19 patients with olfactory disorder (COVID-OD), and 14 controls. A state-of-the-art processing pipeline was developed for DW-MRI pre-processing, mean diffusivity and fractional anisotropy computation, fiber density and cross-section analysis, and tractography of white-matter bundles. Brain parcellation required for probing network connectivity, region-specific microstructure and volume, and cortical thickness was based on T1-weighted scans and anatomical atlases. Results: Compared to controls, COVID-CM patients showed overall gray matter atrophy (age and sex corrected p = 0.004), and both COVID-19 patient groups showed regional atrophy and cortical thinning. Both groups presented an increase in gray matter mean diffusivity (corrected p = 0.001), decrease in white matter fiber density and cross-section (corrected p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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