Deciphering the Epigenetic Symphony of Cancer: Insights and Epigenetic Therapies Implications
| Autor: | Fatima Akram PhD, Rida Tanveer MS, Sahar Andleeb MS, Fatima Iftikhar Shah MPhil, Tayyab Ahmad MBBS, Somia Shehzadi PhD, Abdul Majeed Akhtar MBBS, Ghania Syed MS |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Technology in Cancer Research & Treatment, Vol 23 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1533-0338 15330338 |
| DOI: | 10.1177/15330338241250317 |
| Popis: | Epigenetic machinery is a cornerstone in normal cell development, orchestrating tissue-specific gene expression in mammalian cells. Aberrations in this intricate landscape drive substantial changes in gene function, emerging as a linchpin in cancer etiology and progression. While cancer was conventionally perceived as solely a genetic disorder, its contemporary definition encompasses genetic alterations intertwined with disruptive epigenetic abnormalities. This review explores the profound impact of DNA methylation, histone modifications, and noncoding RNAs on fundamental cellular processes. When these pivotal epigenetic mechanisms undergo disruption, they intricately guide the acquisition of the 6 hallmark characteristics of cancer within seemingly normal cells. Leveraging the latest advancements in decoding these epigenetic intricacies holds immense promise, heralding a new era in developing targeted and more efficacious treatment modalities against cancers driven by aberrant epigenetic modifications. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|