| Autor: |
Vasiliki Papadatou, Stylianos Tologkos, Theodora Deftereou, Triantafyllos Alexiadis, Olga Pagonopoulou, Christina-Angelika Alexiadi, Panagiota Bakatselou, Sadik Tzem Chousein Oglou, Grigorios Tripsianis, Achilleas Mitrakas, Maria Lambropoulou |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Folia Medica, Vol 65, Iss 5, Pp 744-752 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1314-2143 |
| DOI: |
10.3897/folmed.65.e90054 |
| Popis: |
Introduction: Parvoviruses are DNA viruses of small size. There have been a number of reports indicating the possible effects of B19 infections during pregnancy. These effects include spontaneous abortions, stillbirth, fetal damage, and quite often, fetal anemia with hydrops fetalis. Aim: The aim of this study was the correlation of Epstein-Barr virus (EBV) and parvovirus-B19 infections with inflammation levels in placental tissue coming from spontaneous abortions and elective terminations cases. We also investigated whether viral presence could cause spontaneous abortions by associating the expression levels of inflammatory markers with adverse pregnancy outcomes. Materials and methods: One hundred ninety-four placental samples were used, 152 included in the study group coming from spontaneous abortions while 42 controls were used from cases of elective terminations. Hematoxylin and eosin (H&E) staining was performed to investigate morphological changes in the tissues, and then indirect immunohistochemistry to evaluate the expression of TNF-α, IL-6, IL-1α, B19, and EBV. Statistical analysis was performed using SPSS v. 19.0 (IBM). Results: Higher inflammation levels were observed with statistical significance in the spontaneous abortions group (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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