| Autor: |
Zhaoyun Sun, Lei Ding, Wei Tong, Chen Ma, Dinglin Yang, Xiang Guan, Yangfan Xiao, Kailun Xu, Qingguo Li, Cunjing Lv |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Materials & Design, Vol 232, Iss , Pp 112148- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
0264-1275 |
| DOI: |
10.1016/j.matdes.2023.112148 |
| Popis: |
Superhydrophobic coatings are gaining importance not only in military technology, industrial engineering, power systems and transportation, but also in food science and biomedicine, where they have enormous potential for real-time applications. Many research institutes have recently been working on the development of superhydrophobic blood-repellent tubes to replace clinical heparin-coated tubes during ECMO therapy, but biological toxicity and high blood adhesion have significantly hampered their practical applications. In this study, we created a cardiopulmonary bypass tube with good superhydrophobicity and blood repellency. In terms of biotoxicity, coagulation time, protein and platelet adsorption, the results show that the superhydrophobic-treated tube clotted in 36 min, compared to 21 min for a clinical Bioline heparin-coated tube and 14 min for bare PVC tube. When compared to the bare PVC tube, the clotting time of the superhydrophobic-treated tube was increased by 157% due to the Cassie-Baxter wetting state of the resulting superhydrophobic blood-repellent coating. Meanwhile, the protein and platelet adsorption on the superhydrophobic-treated tube were decreased by 32% and 74%, respectively. It should be noted that we were the first to explain the superhydrophobic anti-platelet adsorption mechanism from the perspective of inhibiting thromboxane-A2 secretion during blood coagulation. Clarification of platelet activation process and activating substances is vital for understanding the anticoagulant properties of superhydrophobic coatings. On the other hand, non-inflammatory response of the organism was confirmed in the vivo experiments and the cell viability after a 48-hour cytotoxicity assay was about 101%, indicating that the superhydrophobic-treated tubes are non-toxic. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Full Text from ScienceDirect