Hereditary mechanisms in the development of sclerotic degenerative disorders of aortic valve
Autor: | N. N. Parfenova, S. I. Khasanova, L. B. Mitrofanova, E. V. Dubova, E. V. Zemtsovsky |
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Jazyk: | ruština |
Rok vydání: | 2013 |
Předmět: | |
Zdroj: | Российский кардиологический журнал, Vol 0, Iss 1, Pp 50-53 (2013) |
Druh dokumentu: | article |
ISSN: | 1560-4071 2618-7620 |
DOI: | 10.15829/1560-4071-2013-1-50-53 |
Popis: | Aim. To investigate the role of hereditary mechanisms in the development of sclerotic degenerative disorders of aortic valve. Material and methods. Clinical, phenotypical, and echocardiographic examination was performed in 180 middle-aged and elderly people (mean age 63,8±9 years; 102 men, 78 women), including 86 patients with calcific aortic stenosis (55 after aortic valve surgery) and 61 controls. The diagnostic criteria of the National Guidelines on hereditary connective tissue disorders (2009) were used. The valve biopsy samples were examined using histological, morphological, and immunohistochemical (TGF- |
Databáze: | Directory of Open Access Journals |
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