Synthesis and Cytotoxic Activity of Combretastatin A-4 and 2,3-Diphenyl-2H-indazole Hybrids

Autor: Jaime Pérez-Villanueva, Félix Matadamas-Martínez, Lilián Yépez-Mulia, Vadim Pérez-Koldenkova, Martha Leyte-Lugo, Karen Rodríguez-Villar, Francisco Cortés-Benítez, Ana Perla Macías-Jiménez, Ignacio González-Sánchez, Ariana Romero-Velásquez, Juan Francisco Palacios-Espinosa, Olivia Soria-Arteche
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Pharmaceuticals, Vol 14, Iss 8, p 815 (2021)
Druh dokumentu: article
ISSN: 1424-8247
DOI: 10.3390/ph14080815
Popis: Cancer is the second leading cause of death, after cardiovascular diseases. Different strategies have been developed to treat cancer; however, chemotherapy with cytotoxic agents is still the most widely used treatment approach. Nevertheless, drug resistance to available chemotherapeutic agents is still a serious problem, and the development of new active compounds remains a constant need. Taking advantage of the molecular hybridization approach, in the present work we designed, synthesized, and tested the cytotoxic activity of two hybrid compounds and seven derivatives based on the structure of combretastatin A-4 and 2,3-diphenyl-2H-indazole. Practical modifications of reported synthetic protocols for 2-pheny-2H-indazole and 2,3-dipheny-2H-indazole derivatives under microwave irradiation were implemented. The cytotoxicity assays showed that our designed hybrid compounds possess strong activity, especially compound 5, which resulted even better than the reference drug cisplatin against HeLa and SK-LU-1 cells (IC50 of 0.16 and 6.63 µM, respectively), and it had similar potency to the reference drug imatinib against K562 cells. Additionally, in silico and in vitro studies strongly suggest tubulin as the molecular target for hybrid compound 5.
Databáze: Directory of Open Access Journals
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