| Autor: |
Đorđević P.B., Dimitrijević-Srećković Vesna, Bumbaširević V., Čolović R., Nikolić D., Raketić Nevenka, Ćanović F. |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Archives of Biological Sciences, Vol 61, Iss 1, Pp 9-15 (2009) |
| Druh dokumentu: |
article |
| ISSN: |
0354-4664 |
| DOI: |
10.2298/ABS0901009D |
| Popis: |
We investigated the influence of short-term culture in vitro on the appearance of apoptosis of human fetal pancreatic islets (HFIs) and its effect on the mass and insulin-secretory capacity (ISC) of β-cells. It was found that apoptosis was present from the end of the culture period, increasing as a function of time and leading to decrease of β-cell mass. At the same time, ISC decreased. The decrease of β-cell mass and ISC may influence significantly the clinical outcome of HFIs transplantation in type 1 diabetic patients. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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