| Autor: |
Yongchun Zhou, Lingli Liao, Nan Su, Hua Huang, Yaoguo Yang, Yan Yang, Gengming Wang, Hongbo Xu, Hao Jiang |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Radiation Medicine and Protection, Vol 3, Iss 3, Pp 139-145 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2666-5557 |
| DOI: |
10.1016/j.radmp.2022.05.003 |
| Popis: |
Objective: To define the properties of lung cancer cells that resisted conventionally fractionated radiation exposure. Methods: Acquired radioresistant lung cancer cell line A549 was constructed by X-ray irradiation with a clinical conventional fraction dose of 2 Gy daily during 30 fractions. Cell morphology, molecular markers, migration capacity and invasion potential were evaluated by the microscope, Western blot, immunofluorescence, wound healing test and transwell chamber assay, respectively. Results: Radioresistant A549 cells shifted from an epithelial to a mesenchymal morphology, termed as epithelial-mesenchymal transition (EMT), and was accompanied by decreased expressions of epithelial markers (F = 4.568, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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