Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling

Autor: Feng Xie, Xiaoxue Zhou, Peng Su, Heyu Li, Yifei Tu, Jinjin Du, Chen Pan, Xiang Wei, Min Zheng, Ke Jin, Liyan Miao, Chao Wang, Xuli Meng, Hans van Dam, Peter ten Dijke, Long Zhang, Fangfang Zhou
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-31250-2
Popis: Understanding the factors that hamper immune therapy in breast cancer may increase the range of patients who benefit. Here authors show that breast cancer cells produce and subsequently transfer active TGF-β type II receptors to CD8 + T cells to render them exhausted, thus paralyzing the anti-tumor immune response.
Databáze: Directory of Open Access Journals