Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases

Autor:	Jason A. Chen, Zhongbo Chen, Hyejung Won, Alden Y. Huang, Jennifer K. Lowe, Kevin Wojta, Jennifer S. Yokoyama, Gilbert Bensimon, P. Nigel Leigh, Christine Payan, Aleksey Shatunov, Ashley R. Jones, Cathryn M. Lewis, Panagiotis Deloukas, Philippe Amouyel, Christophe Tzourio, Jean-Francois Dartigues, Albert Ludolph, Adam L. Boxer, Jeff M. Bronstein, Ammar Al-Chalabi, Daniel H. Geschwind, Giovanni Coppola
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Genome-wide association study Progressive supranuclear palsy Neurodegeneration Neurology. Diseases of the nervous system RC346-429 Geriatrics RC952-954.6
Zdroj:	Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-11 (2018)
Druh dokumentu:	article
ISSN:	1750-1326
DOI:	10.1186/s13024-018-0270-8
Popis:	Abstract Background Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease for which the genetic contribution is incompletely understood. Methods We conducted a joint analysis of 5,523,934 imputed SNPs in two newly-genotyped progressive supranuclear palsy cohorts, primarily derived from two clinical trials (Allon davunetide and NNIPPS riluzole trials in PSP) and a previously published genome-wide association study (GWAS), in total comprising 1646 cases and 10,662 controls of European ancestry. Results We identified 5 associated loci at a genome-wide significance threshold P
Databáze:	Directory of Open Access Journals
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