Transpelvic Magnetic Stimulation Enhances Penile Microvascular Perfusion in a Rat Model: A Novel Interventional Strategy to Prevent Penile Fibrosis after Cavernosal Nerve Injury

Autor: Samuel Sorkhi, Christopher Cano Sanchez, Min Chul Cho, Sung Yong Cho, Hong Chung, Min Gu Park, Susan Lahey, Tung-Chin Hsieh, Valmik Bhargava, Mahadevan Raj Rajasekaran
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: The World Journal of Men's Health, Vol 40, Iss 3, Pp 501-508 (2022)
Druh dokumentu: article
ISSN: 2287-4208
2287-4690
DOI: 10.5534/wjmh.210162
Popis: Purpose:Purpose: Penile microvascular dysfunction is a known contributor to erectile dysfunction (ED) and penile fibrosis has been shown to impair microvascular perfusion (MVP). Our objectives were to: (i) determine beneficial effects of TPMS to modulate penile MVP, (ii) determine its mechanism, (iii) evaluate impact of cavernosal nerve injury (CNI) on penile MVP, and (iv) deter-mine time-course of cavernosal tissue elastin changes after CNI in rats. Materials Materials and and Methods:Methods: Adult male rats (n=5) were anesthetized and subjected to TPMS (13%, 15%, and 17%) and MVP changes were recorded using laser speckle contrast imaging (LSCI). Another group of male rats were subjected to either bi-lateral cavernosal nerve injury (CNI; n=7) or sham surgery (n=7). After recovery, animals were monitored for MVP using LSCI before and after TPMS. Rat penile tissues were harvested and analyzed for fibrosis using a marker for elastin. Results:Results: Rat TPMS resulted in a stimulus dependent increase in MVP; maximal perfusion was observed at 17%. L-N(G)-Nitroarginine methyl ester (L-NAME) resulted in a marked decrease in TPMS induced MVP increase (393.33 AU vs. 210.67 AU). CNI resulted in 40% to 50% decrease in MVP. CNI produced a remarkable increase in elastin deposits that are notice-able throughout the cavernosal tissues post injury. Conclusions:Conclusions: TPMS is a novel and non-invasive intervention to improve penile MVP after CNI. Potential application includes treatment of ED and sexual function preservation following cancer treatment, possibly through improved penile hemodynam-ics that might help prevent penile hypoxia and fibrosis.
Databáze: Directory of Open Access Journals
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