A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance

Autor: Chiara Milanese, Pier G. Mastroberardino
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Molecular & Cellular Oncology, Vol 7, Iss 3 (2020)
Druh dokumentu: article
ISSN: 2372-3556
23723556
DOI: 10.1080/23723556.2020.1733383
Popis: Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and reductive stress. Here, we highlight the relevance of these findings for cancer and chemoresistance development.
Databáze: Directory of Open Access Journals
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