| Autor: |
Jian Song, Hong-Li Wang, Ke-Han Song, Zhi-Wen Ding, Hai-Lian Wang, Xiao-Sheng Ma, Fei-Zhou Lu, Xin-Lei Xia, Ying-Wei Wang, Fei-Zou, Jian-Yuan Jiang |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Experimental and Molecular Medicine, Vol 50, Iss 8, Pp 1-12 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2092-6413 |
| DOI: |
10.1038/s12276-018-0125-y |
| Popis: |
Spinal disease: A roundabout route to disc degeneration ‘RNA sponges’ may provoke lower back pain by soaking up regulatory RNAs that normally protect the protein infrastructure surrounding cells in intervertebral discs. Many people suffer from lower back pain arising from disc degeneration (IDD). A team led by Fei-Zou and Jian-Yuan Jiang at Fudan University, Shanghai, China set out to identify molecular mechanisms that might contribute to IDD. They focused on circular RNAs, non-protein coding RNAs that have been linked to a variety of diseases. The researchers learned that IDD is associated with strongly elevated expression of a circular RNA that acts as an ‘RNA sponge’, binding to and thereby inactivating other RNA molecules. This inactivation ultimately results in the excessive production of an enzyme that can damage the protein matrix that supports cells within spinal discs, potentially setting up the conditions for IDD. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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