A high-fructose diet induces insulin resistance but not blood pressure changes in normotensive rats
Autor: | R.M.N. Bezerra, M. Ueno, M.S. Silva, D.Q. Tavares, C.R.O. Carvalho, M.J.A. Saad, J.A.R. Gontijo |
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Jazyk: | angličtina |
Rok vydání: | 2001 |
Předmět: | |
Zdroj: | Brazilian Journal of Medical and Biological Research, Vol 34, Iss 9, Pp 1155-1160 (2001) |
Druh dokumentu: | article |
ISSN: | 0100-879X 1414-431X |
DOI: | 10.1590/S0100-879X2001000900008 |
Popis: | Rats fed a high-fructose diet represent an animal model for insulin resistance and hypertension. We recently showed that a high-fructose diet containing vegetable oil but a normal sodium/potassium ratio induced mild insulin resistance with decreased insulin receptor substrate-1 tyrosine phosphorylation in the liver and muscle of normal rats. In the present study, we examined the mean blood pressure, serum lipid levels and insulin sensitivity by estimating in vivo insulin activity using the 15-min intravenous insulin tolerance test (ITT, 0.5 ml of 6 µg insulin, iv) followed by calculation of the rate constant for plasma glucose disappearance (Kitt) in male Wistar-Hannover rats (110-130 g) randomly divided into four diet groups: control, 1:3 sodium/potassium ratio (R Na:K) diet (C 1:3 R Na:K); control, 1:1 sodium/potassium ratio diet (CNa 1:1 R Na:K); high-fructose, 1:3 sodium/potassium ratio diet (F 1:3 R Na:K), and high-fructose, 1:1 sodium/potassium ratio diet (FNa 1:1 R Na:K) for 28 days. The change in R Na:K for the control and high-fructose diets had no effect on insulin sensitivity measured by ITT. In contrast, the 1:1 R Na:K increased blood pressure in rats receiving the control and high-fructose diets from 117 ± 3 and 118 ± 3 mmHg to 141 ± 4 and 132 ± 4 mmHg (P |
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