| Autor: |
Xin Li, Jia Bao, Liya Ai, Fan‐Rui Yang, Bo Yu, Yan‐Ping Huang, Na Li, Wen‐Yuan Ding, Zhi‐Qiang Sun, Xin‐Xiang Lv, Jian‐Wen Han |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Molecular Genetics & Genomic Medicine, Vol 12, Iss 11, Pp n/a-n/a (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2324-9269 |
| DOI: |
10.1002/mgg3.70021 |
| Popis: |
ABSTRACT Background This study aimed to investigate the association between genetic variants of ERAP1 (OMIM: 606832) and psoriasis vulgaris (PsV) susceptibility in Inner Mongolia Han nationality. Methods For primary screening, the subjects included 142 PsV cases and 100 healthy controls without psoriasis. The 27 exons of ERAP1 gene were sequenced to screen significant genetic variants. For the validation study, the subjects included 1030 PsV cases and 965 healthy controls. A total of 18 mutations were detected for genetic variants of significance in primary screening and previously reported genetic variants. Results In primary screening stage, 13 genetic variants of ERAP1 showed an association with psoriasis. A total of 18 genetic variants were typed for the validation, and 12 genetic variants were associated with PsV in Inner Mongolia Han population. Stratified analysis showed significant differences in the allele frequencies of 8 ERAP1 genetic variants in cases with positive family history, and significant differences in allele frequencies among 9 ERAP1 genetic variants in patients with negative family history. A risk haplotype (TCCCTCCAGACC) was significantly associated with PsV, and the most risk haplotype was E730/K528/R127/E56. Conclusion ERAP1 gene mutation may be associated with PsV and HLA‐C*06:02 in Han nationality in Inner Mongolia. A risk haplotype of four‐nonsynonymous mutation (E730/K528/R127/E56) is associated with PsV. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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