| Autor: |
Marta Mitiko Deguti, Debora Raquel Benedita Terrabuio, Fabiana Cordeiro Araújo, Gilda Porta, Egberto Reis Barbosa, Eduardo Luiz Rachid Cançado |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Annals of Hepatology, Vol 29, Iss , Pp 101613- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1665-2681 |
| DOI: |
10.1016/j.aohep.2024.101613 |
| Popis: |
Conflict of interest: No Introduction and Objectives: Wilson disease (WD) is an inherited disease that mainly affects the liver and brain due to copper overload. Pregnancy in WD is a challenging situation. Our aim was to analyze the clinical aspects and outcomes of pregnancies in WD. Patients / Materials and Methods: In a series of 289 WD cases (1963-2024), we reviewed the medical records of 123 women, 26 of whom became pregnant at least once (1-5). A total of 52 pregnancies were recorded, but 3 were excluded because data on the conceptus were missing. Pregnancy outcomes were correlated with disease severity and anti-copper medication. Hepatic and/or neuropsychiatric manifestations were categorized as 1) asymptomatic/mild or 2) moderate/severe. Pregnancy outcomes were considered 1) successful if the preterm/term infant survived the neonatal period or 2) unsuccessful if there was a miscarriage/fetal demise/perinatal death. Drug regimen during pregnancy were 1) penicillamine (DPA), 2) zinc (Zn) or 3) DPA/Zn if the patient had switched therapy for any reason. Statistical analysis was carried out using Fisher´s test, with significance level at p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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