| Autor: |
Rodolfo Guelman, Ariel Sánchez, Mariela Varsavsky, Lucas R. Brun, María Laura García, Marcelo Sarli, Rey Paula, Vanina Farias, María Belén Zanchetta, Evangelina Giacoia, Helena Salerni, Laura Maffei, Valeria Premrou, Beatriz Oliveri, María Lorena Brance, Magdalena Pavlove, Silvia Karlsbrum, María Silvia Larroudé, Pablo René Costanzo |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
International Journal of Endocrinology, Vol 2023 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1687-8345 |
| DOI: |
10.1155/2023/9355672 |
| Popis: |
Purpose. To evaluate the effect of teriparatide (TPTD) on bone mineral density (BMD) and bone markers under clinical practice conditions. To assess whether the results in real-life match those published in clinical trials. Methods. Cross-sectional study of postmenopausal women treated with TPTD for at least 12 months. Results. 264 patients were included in the study. Main characteristics are as follows: age: 68.7 ± 10.2 years, previous fractures: 57.6%, and previously treated with antiresorptive (AR-prior): 79%. All bone turnover markers studied significantly increased after 6 months. CTX and BGP remained high up to 24 months, but total and bone alkaline phosphatase returned to basal values at month 18. There was a significant increase in lumbar spine (LS) BMD after 6 months (+6.2%), with a maximum peak at 24 months (+13%). Femoral neck (FN) and total hip (TH) BMD showed a significant increase later than LS (just at month 12), reaching a maximum peak at month 24 (FN + 7.9% and TH + 5.5%). A significant increase in LS BMD was found from month 6 to month 24 compared to basal in both AR-naïve, and AR-prior patients (+16.7% and +10.5%, respectively), without significant differences between the two groups. Comparable results were found in FN and TH BMD. Main conclusions. As reported in real-life clinical studies, treatment of osteoporotic postmenopausal women with TPTD induced a significant increase in bone turnover markers from month 6 onward and an increase in BMD from months 6–12 with continuous gain up to month 24. The real-life results of our study matched the results of randomized clinical trials. In addition, TPTD induced an increase in BMD, regardless of the previous use of AR. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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