Structural and functional analysis of EntV reveals a 12 amino acid fragment protective against fungal infections

Autor: Melissa R. Cruz, Shane Cristy, Shantanu Guha, Giuseppe Buda De Cesare, Elena Evdokimova, Hiram Sanchez, Dominika Borek, Pedro Miramón, Junko Yano, Paul L. Fidel, Alexei Savchenko, David R. Andes, Peter J. Stogios, Michael C. Lorenz, Danielle A. Garsin
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-33613-1
Popis: Enterococcus faecalis has been reported to inhibit Candida albicans virulence via secretion of the bacteriocin EntV. Here, the authors present the crystal structure and characterise the antifungal properties of this peptide in numerous in vitro and in vivo assays.
Databáze: Directory of Open Access Journals
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