Association of corticosteroid therapy with reduced acute kidney injury and lower NET markers in severe COVID-19: an observational study

Autor: Sara Bülow Anderberg, Joram Huckriede, Michael Hultström, Anders Larsson, Femke de Vries, Miklos Lipcsey, Gerry A. F. Nicolaes, Robert Frithiof
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Intensive Care Medicine Experimental, Vol 12, Iss 1, Pp 1-15 (2024)
Druh dokumentu: article
ISSN: 2197-425X
DOI: 10.1186/s40635-024-00670-3
Popis: Abstract Background Acute kidney injury (AKI) is common in critical cases of coronavirus disease 2019 (COVID-19) and associated with worse outcome. Dysregulated neutrophil extracellular trap (NET) formation is one of several suggested pathophysiological mechanisms involved in the development of COVID-19 associated AKI. The corticosteroid dexamethasone was implemented as a standard treatment for severe COVID-19 as of June 2020. A sub-analysis of a prospective observational single center study was performed to evaluate the effect of corticosteroid treatment on AKI development and NET markers in critical cases of COVID-19. Results Two hundred and ten adult patients admitted to intensive care at a tertiary level hospital due to respiratory failure or shock secondary to SARS-CoV-2-infection between March 13th 2020 and January 14th 2021 were included in the study. Ninety-seven of those did not receive corticosteroids. One hundred and thirteen patients were treated with corticosteroids [dexamethasone (n = 98) or equivalent treatment (n = 15)], but the incidence of AKI was assessed only in patients that received corticosteroids before any registered renal dysfunction (n = 63). Corticosteroids were associated with a lower incidence of AKI (19% vs 55.8%, p
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