EEG Resting State Functional Connectivity in Adult Dyslexics Using Phase Lag Index and Graph Analysis

Autor: Gorka Fraga González, Dirk J. A. Smit, Melle J. W. van der Molen, Jurgen Tijms, Cornelis Jan Stam, Eco J. C. de Geus, Maurits W. van der Molen
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Frontiers in Human Neuroscience, Vol 12 (2018)
Druh dokumentu: article
ISSN: 1662-5161
DOI: 10.3389/fnhum.2018.00341
Popis: Developmental dyslexia may involve deficits in functional connectivity across widespread brain networks that enable fluent reading. We investigated the large-scale organization of electroencephalography (EEG) functional networks at rest in 28 dyslexics and 36 typically reading adults. For each frequency band (delta, theta alpha and beta), we assessed functional connectivity strength with the phase lag index (PLI). Network topology was examined using minimum spanning tree (MST) graphs derived from the functional connectivity matrices. We found significant group differences in the alpha band (8–13 Hz). The graph analysis indicated more interconnected nodes, in dyslexics compared to typical readers. The graph metrics were significantly correlated with age in dyslexics but not in typical readers, which may indicate more heterogeneity in maturation of brain networks in dyslexics. The present findings support the involvement of alpha oscillations in higher cognition and the sensitivity of graph metrics to characterize functional networks in adult dyslexia. Finally, the current results extend our previous findings on children.
Databáze: Directory of Open Access Journals