| Autor: |
MIRJANA POPSAVIN, NEBOJSA ANDRIC, SLOBODANKA STANKOVIC, SUZANA JOVANOVIC-SANTA, EVGENIJA DJURENDIC, MARIJA SAKAC, SRDJAN STOJANOVIC, KATARINA PENOV-GASI |
| Jazyk: |
angličtina |
| Rok vydání: |
2003 |
| Předmět: |
|
| Zdroj: |
Journal of the Serbian Chemical Society, Vol 68, Iss 10, Pp 707-714 (2003) |
| Druh dokumentu: |
article |
| ISSN: |
0352-5139 |
| Popis: |
Starting from 3b-acetoxy-15-cyano-17-oxo-16,17-seco-5-androstene (2) and 3b-acetoxy-15-cyano-17-hydroxy-17-methyl-16,17-seco-5-androstene (11), new 17-halo-derivatives (510 and 13) were obtained. The fluoro derivative 5 was obtained from 17-tosylate 4 in reaction with tetrabutylammonium fluoride. The structure of the 17-iodo-devitive 10 was unambiguously proved by the appropriate X-ray structural analysis. Compounds 510, as well as 12 and 13, were tested for possible anti-aromatase activity, whereby only compound 9, with bromine as the C-17 substituent, induced 19.4 % inhibition of aromatase activity compared to the control. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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