Modulation of corticosterone and changes of signal molecules in the HPA axis after cold water swimming stress

Autor: Jing Hui Feng, Su Min Sim, Jung Seok Park, Jae Seung Hong, HongWon Suh
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Animal Cells and Systems, Vol 25, Iss 1, Pp 37-45 (2021)
Druh dokumentu: article
ISSN: 1976-8354
2151-2485
19768354
DOI: 10.1080/19768354.2021.1890211
Popis: In the present study, we examined the effect of cold-water swimming stress (CWSS) on plasma corticosterone levels. Mice were exposed to stress in 4°C for 3 mins. Plasma corticosterone (CORT) level was measured at 0, 15, and 30 min after stress stimulation. The plasma CORT level was gradually increased up to 30 min. Then we further examined the changes of several signaling molecules expression levels, such as p-ERK, p-JNK, p-P38, p-AMPKα1, p-AMPKα2, and p-mTOR, in the HPA axis. We observed that those signaling molecules were altered after stress in the HPA axis. p-ERK, p-JNK, p-P38, and p-mTOR proteins expression were reduced by CWSS in the HPA axis. However, the phosphorylation of AMPKα1 and AMPKα2 were activated after CWSS in the HPA axis. Our results suggest that the upregulation of plasma CORT level induced by CWSS may be modulated by the those signaling molecules.
Databáze: Directory of Open Access Journals
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