Circulating metabolites and molecular lipid species are associated with future cardiovascular morbidity and mortality in type 1 diabetes

Autor: Luis F. Ferreira-Divino, Tommi Suvitaival, Viktor Rotbain Curovic, Nete Tofte, Kajetan Trošt, Ismo M. Mattila, Simone Theilade, Signe A. Winther, Tine W. Hansen, Marie Frimodt-Møller, Cristina Legido-Quigley, Peter Rossing
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-10 (2022)
Druh dokumentu: article
ISSN: 1475-2840
11999640
DOI: 10.1186/s12933-022-01568-8
Popis: Abstract Background Cardiovascular disease remains the leading cause of mortality in individuals with diabetes and improved understanding of its pathophysiology is needed. We investigated the association of a large panel of metabolites and molecular lipid species with future cardiovascular events in type 1 diabetes. Methods The study included 669 individuals with type 1 diabetes. Non-targeted serum metabolomics and lipidomics analyses were performed using mass spectrometry. Data on cardiovascular events (cardiovascular mortality, coronary artery disease, stroke, and peripheral arterial interventions) were obtained from Danish Health registries and analyzed by Cox hazards models. Metabolites and molecular lipid species were analyzed in univariate models adjusted for false discovery rate (FDR). Metabolites and molecular lipid species fulfilling a pFDR
Databáze: Directory of Open Access Journals
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