A single chemotherapy administration induces muscle atrophy, mitochondrial alterations and apoptosis in breast cancer patients

Autor: Joris Mallard, Elyse Hucteau, Laura Bender, Fabien Moinard‐Butot, Emma Rochelle, Lauréline Boutonnet, Antoine Grandperrin, Roland Schott, Carole Pflumio, Philippe Trensz, Michal Kalish‐Weindling, Anne‐Laure Charles, Bernard Gény, Fabrice Favret, Xavier Pivot, Thomas J. Hureau, Allan F. Pagano
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 1, Pp 292-305 (2024)
Druh dokumentu: article
ISSN: 2190-6009
2190-5991
DOI: 10.1002/jcsm.13414
Popis: Abstract Background Breast cancer patients are commonly treated with sequential administrations of epirubicin–cyclophosphamide (EC) and paclitaxel (TAX). The chronic effect of this treatment induces skeletal muscle alterations, but the specific effect of each chemotherapy agent is unknown. This study aimed to investigate the effect of EC or TAX administration on skeletal muscle homeostasis in breast cancer patients. Methods Twenty early breast cancer patients undergoing EC followed by TAX chemotherapies were included. Two groups of 10 women were established and performed vastus lateralis skeletal muscle biopsies either before the first administration (pre) of EC (50 ± 14 years) or TAX (50 ± 16 years) and 4 days later (post). Mitochondrial respiratory capacity recording, reactive oxygen species production, western blotting and histological analyses were performed. Results Decrease in muscle fibres cross‐sectional area was only observed post‐EC (−25%; P
Databáze: Directory of Open Access Journals
Externí odkaz: