| Autor: |
Miriam G. Bautista-Ubaldo, Gabriela Gutiérrez-Reyes, Ignacio González-Sánchez, Armando Pérez-Torres, Carolina Guzmán |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Annals of Hepatology, Vol 29, Iss , Pp 101453- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1665-2681 |
| DOI: |
10.1016/j.aohep.2024.101453 |
| Popis: |
Introduction and Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent worldwide, the concomitant presence of fibrosis is considered the most important risk factor of cardiovascular death. IGFBP2 is expressed mainly in the liver and at very low levels in heart. This peptide is associated with metabolic affection including obesity and type 2 diabetes. IGFBP2 role in MASLD is not clear. We aimed to assess the expression of IGFBP2 protein in the liver and associate it with its blood levels and cardiac expression in a rodent model of MASLD. Materials and Patients: Male C57BL/6 mice weighing 23±2g were included and fed a high-fat diet with water added with sugar (HF-SF) or control diet up to 30 weeks. Liver damage was assessed by biopsy. IGFBP2 was assayed by ELISA in serum, liver, and heart. Data is shown as Mean±SD, analyzed by ANOVA, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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