The Use of Coupled Plasma Filtration Adsorption in Traumatic Rhabdomyolysis

Autor:	Mario Pezzi, Silvia Renda, Anna Maria Giglio, Anna Maria Scozzafava, Simona Paola Tiburzi, Patrizia Casella, Fabrizio Iannelli, Mario Verre
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
Zdroj:	Case Reports in Critical Care, Vol 2017 (2017)
Druh dokumentu:	article
ISSN:	2090-6420 2090-6439
DOI:	10.1155/2017/5764961
Popis:	Severe musculoskeletal injuries induce the release of sarcoplasmic elements such as muscle enzymes, potassium, and myoglobin in the systemic circulation. The circulating myoglobin damages the glomerulus and renal tubules. Conventional haemodialysis is not able to remove myoglobin, due to its high molecular weight (17,8 kilodaltons [kDa]). We treated four traumatic rhabdomyolysis patients with Coupled Plasma Filtration Adsorption (CPFA) in order to remove myoglobin followed by 14 hours of Continuous Veno-Venous Hemofiltration (CVVH). During the treatment, all patients showed clinical improvement with a decrease in muscular (creatine kinase [CK] and myoglobin) and renal (creatinine and potassium) damage indices. One patient, in spite of full renal recovery, died of cerebral haemorrhage on the 26th day of hospital stay.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/d38911154a13447e9fd32f92cdfa67fa Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF