Heart rate variability and hemostatic parameters in patients with coronary heart disease and chronic heart failure

Autor: M. Z. Buy, A. Yu. Lebedeva, I. G. Gordeev, N. A. Volov, E. O. Taratukhin
Jazyk: ruština
Rok vydání: 2013
Předmět:
Zdroj: Российский кардиологический журнал, Vol 0, Iss 5, Pp 6-11 (2013)
Druh dokumentu: article
ISSN: 1560-4071
2618-7620
DOI: 10.15829/1560-4071-2013-5-6-11
Popis: Aim. To assess the association between the changes in heart rate variability (HRV) and hemostatic parameters in patients with coronary heart disease (CHD) and chronic heart failure (CHF) as its complication. Material and methods. In total, 65 patients were examined at theO.M.FilatovCityClinicalHospital No. 15. The main group included 51 patients with CHD and CHF (35 men, 16 women; mean age 62Ѓ}6 years). The control group included 14 CHD-free patients with arterial hypertension (7 men, 7 women; mean age 56Ѓ}7 years). The examination included standard methods, plus the assessment of HRV and a wide range of coagulogram parameters. Results. CHD patients with CHF demonstrated the hyperactivation of sympathetic nervous system, which was manifested in increased LF/HF (up to 2,5 U), together with the suppression of parasympathetic activity (SDNNi decrease up to 39,1 ms; p2,0 U), protrombin time was reduced by 10,9%, while hematocrit was increased by 10,2%. In patients with elevated spontaneous platelet aggregation, increased sympathetic tone during nighttime was manifested in the reduction of mean cardiac interval duration (893,1Ѓ}111,5 ms vs. 982,7Ѓ}66,7 ms; p2,0) was associated with a significant reduction (–20%) in ADP-induced platelet aggregation. Conclusion. Chronic pathological sympathetic hyperactivation in patients with CHD and CHF affects hemocoagulation parameters. Increased spontaneous platelet aggregation, reduced protrombin time, and elevated hematocrit, together with catecholamine-induced vasospasm, might increase the risk of thrombotic complications.
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